WOBURN, MASSACHUSSETTS – Biotech startup, Frequency Therapeutics, announced late last month the successful completion of a first-in-human study of the company’s investigative compound FX-322, the company’s lead Progenitor Cell Activation candidate for hearing restoration.The preliminary results were recently presented at a lecture last month at the US-Japan Symposium on Drug Delivery. I have especially emphasized Polichem’s P-3074 (now Almirall’s ALM12845) hydroxypropyl chitosan (HPCH)-based topical finasteride. In a FX-322 Phase 1/2 study, statistically significant and clinically meaningful improvements in key measures of hearing function in patients with sensorineural hearing loss were observed. One of the potential negative effects of chemotherapy that you may not be aware of is hearing loss. WOBURN, MASSACHUSETTS – Frequency Therapeutics, Inc. (Nasdaq: FREQ), a clinical-stage biotechnology company focused on harnessing the body’s innate biology to repair or reverse damage caused by a broad range of degenerative diseases, today presented clinical results from a longer-term durability study of FX-322, showing that some patients with chronic sensorineural hearing loss had significant improvement in key measures of hearing that were sustained for up to 21 months. Inner ear cells of humans and other mammals lack the capacity to divide or regenerate; therefore, damage to the inner ear, in particular to the hair cells, leads to permanent hearing loss. Further study Around one in six people in the UK live with some form of hearing loss, mostly age-related, and the problem is expected to worsen in the coming years … is necessary to determine what druglike molecules can achieve cell division and The FX-322 Phase 2a study remains ongoing and the Company is expected to report study data in the second quarter of 2021. Your doctor will also look for any structural causes of your hearing problems. “Today’s announcement is another important building block as we further our understanding of FX-322’s drug potential and the patient populations we hope to treat. Types, Causes and Treatment Genetics and Hearing Loss Prepare for Appointments ... 2020 Jan/Feb. Today is World Hearing Day, an annual global initiative from the World Health Organization to promote hearing care and raise awareness of hearing loss. DOI: 10.1038/s41598-020-64498-z. Last medically reviewed on October 6, 2020 For information on Telemedicine availability and office updates related to COVID-19, please visit our informational page: Please prove you are human by selecting the, senior study author Zheng-Yi Chen explained. About 9 percent of those aged between 55 and 64 have a disabling hearing loss, and an entire 25 percent of adults between the ages of 65 and 74 are also affected by the same condition. The most common cause of auditory loss is age, and it is believed that after 75, 50 percent of older adults will lose all or part of their hearing. In addition to a favorable safety profile, we have generated compelling cochlear, FX-322 is currently being evaluated in a Phase 2a study. Oticon Inc. Launches More™: First tHearing Aid with an On-Board Deep Neural Network. The federal Clinical Trials registrystates the trial "will assess the exploratory efficacy, as well as the local and systemic safety of single and repeat intratympanic doses of FX-322 compared to placebo in approximately 96 subjects with stable mild to moderately severe sensorineural hearing loss, with a medical history consistent with either excessive noise exposure or idiopathic sudden sensorineural hearing loss." Luckily, a new front runner for the guide was not hard to find. These patients had received a single intratympanic dose of FX-322 in a double-blind, placebo- controlled study, and had been evaluated for 90 days. SNHL impacts more than 40 million people in the U.S. and hundreds of millions of people globally and is the primary cause of more than 90 percent of all hearing loss. You can purchase the latest hearing aids at a fair price through HearingSol, If you need any assistance or you have a query regarding Tinnitus Treatment or Hearing Loss, feel free to call us at +91-9899437202. While any hearing aid can minimize the symptoms of tinnitus by improving your hearing function, there are hearing aids from Signia with special functions for tackling tinnitus. Access to effective treatment was already limited prior to the pandemic, with many people waiting months for therapy on the NHS. The Phase 2a study has four dose cohorts, and hearing function will be regularly tested over the course of seven months following the first dosing. Hearing loss can be caused by plenty of reasons. Copyright © HHTM, 2020. The Company’s progenitor cell activation (PCA) approach stimulates progenitor cells to create functional tissue with the aim of developing disease modifying therapies. The objectives of the Phase, 2a study are to further establish the hearing signal observed in the completed, Survey Finds Remote Audiology Appointments Beneficial, Researchers Identify Role of Crucial Protein in Development of New Inner Ear Hair Cells. Susan King, M.D., FACS, the lead investigator on both studies, detailed results today at the AAO-HNS 2020 Virtual Annual Meeting & OTO Experience. Due to this, wearing hearing aids is often the first-line treatment. A concise guide to the functional communication assessment. We are always here to help you. study is significant in that it shows it may, in fact, be possible to reverse A recent study investigates ways to regrow the ear's all-important sensory hairs. US Hearing Aid Pricing: Part 3 – Nominal Retail-Side Trends. While most ear infections that lead to hearing loss are viral-based, garlic can fight infections caused by bacteria. Through the Stanford Initiative to Cure Hearing Loss , more than a hundred scientists and technicians are working to cure inner-ear hearing loss — the type that results from hair cell degeneration — which remains incurable today. The FX-322 Phase 2a study is a randomized, double blind, placebo-controlled, single- and repeat-dose study in which the Company plans to enroll up to 96 patients aged 18 to 65 with SNHL. The charity Action on Hearing Loss has said that medication to treat hearing loss could be ready by 2020, with five drugs in the final stages of clinical testing and a further 13 in the early stages of clinical development. Frequency Therapeutics is a leader in the development of medicines designed to activate progenitor cells within the body to treat degenerative diseases. By identifying proteins that spur the birth of new hair cells in the cochlea, new research in mice paves the way to new treatments for hearing loss. Buy and download your eBook now at Shopify. During the The main types of hearing loss are sensorineural, conductive, or a combination of both. ENT of Athens is committed to your health and safety. Your email address will not be published. document.getElementById("comment").setAttribute( "id", "ae946aa91159da39fe40a20ea63fbdc3" );document.getElementById("dd5fff0ec9").setAttribute( "id", "comment" ); Get HHTM Weekly, our free email newsletter. To determine The FX-322 Phase 2a study is a randomized, double blind, placebo-controlled, single- and repeat-dose study in which the Company plans to enroll up to 96 patients aged 18 to 65 with SNHL. The face of severe tinnitus and unexplained hearing loss that most often occurs during aging damage to brain. 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